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Real-Time Detection and Monitoring of Acute Brain Injury Utilizing Evoked Electroencephalographic Potentials

Jonathan AN Fisher, Stanley Huang, Meijun Ye, Marjan Nabili, W Bryan Wilent, Victor Krauthamer, Matthew R Myers, Cristin G Welle

Rapid detection and diagnosis of a traumatic brain injury (TBI) can significantly improve the prognosis for recovery. Helmet-mounted sensors that detect impact severity based on measurements of acceleration or pressure show promise for aiding triage and transport decisions in active, field environments such as professional sports or military combat. The detected signals, however, report on the mechanics of an impact rather than directly indicating the presence and severity of an injury. We explored the use of cortical somatosensory evoked electroencephalographic potentials (SSEPs) to detect and track, in real-time, neural electrophysiological abnormalities within the first hour following head injury in an animal model. To study the immediate electrophysiological effects of injury in vivo, we developed an experimental paradigm involving focused ultrasound that permits continuous, real-time measurements and …

Publication Date:

2016/3/1

Journal:

IEEE Transactions on Neural Systems and Rehabilitation Engineering

Volume:

24

Issue:

9

BIOElectrics Lab

Led by Cristin Welle, PhD

Department of Neurosurgery

12800 East 19th Avenue
Room RC1N 7118
Aurora, CO 80045

office: (303) 724-9116

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