Using rodent models, we evaluate the long-term recording quality and tissue response to multielectrode recording electrode arrays implanted in primary motor cortex and the peripheral nervous system.
NEUROMODULATION TO ACCELERATE MOTOR LEARNING
Vagal nerve stimulation (VNS) currently treats patients with epilepsy and depression. In addition, it may also produce cortical plasticity, and drive learning and rehabilitation. We are using animal models to understand the mechanisms of VNS-driven cortical plasticity, specifically to enhance motor learning.
HUMAN BRAIN TISSUE ANALYSIS
Deep brain stimulation (DBS) is used to treat patients with Parkinson's, essential tremor and obsessive compulsive disorder. Using brain samples from human patients, we are evaluating the long-term safety of DBS, along with the potential for neuroprotective effects.