RESEARCH PROJECTS

BRAIN COMPUTER INTERFACE (BCI) SYSTEMS

Using rodent models, we evaluate the long-term recording quality and tissue response to multielectrode recording electrode arrays implanted in primary motor cortex and the peripheral nervous system.

NEUROMODULATION

Deep brain stimulation (DBS) is used to treat patients with Parkinson's, essential tremor and obsessive compulsive disorder. Using brain samples from human patients, we are evaluating the long-term safety of DBS, along with the potential for neuroprotective effects.

Vagal nerve stimulation (VNS) currently treats patients with epilepsy and depression. In addition, it may also produce cortical plasticity, and could drive learning. We are using animal models to understand the mechanisms of VNS-driven cortical plasticity.

IN VIVO AND EX VIVO VOLUMETRIC TISSUE IMAGING

To compliment our BCI and Neuromodulation goals, we are utilizing multiphoton microscopy to image large tissue volumes in vivo and in CLARITY-clearned ex vivo tissue.