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Closed-loop automated reaching apparatus (CLARA) for interrogating motor systems.

S Bowles, WR Williamson, D Nettles, J Hickman, CG Welle

Objective:

Closed-loop neuromodulation technology is a rapidly expanding category of therapeutics for a broad range of indications. Development of these innovative neurological devices requires high-throughput systems for closed-loop stimulation of model organisms, while monitoring physiological signals and complex, naturalistic behaviors. To address this need, we developed CLARA, a closed-loop automated reaching apparatus.


Approach:

Using breakthroughs in computer vision, CLARA integrates fully-automated, markerless kinematic tracking of multiple features to classify animal behavior and precisely deliver neural stimulation based on behavioral outcomes. CLARA is compatible with advanced neurophysiological tools, enabling the testing of neurostimulation devices and identification of novel neurological biomarkers.


Results:

The CLARA system tracks unconstrained skilled reach behavior in 3D at 150 …

Publication Date:

2021/8/31

Journal:

Journal of Neural Engineering

Volume:

18

Issue:

4

BIOElectrics Lab

Led by Cristin Welle, PhD

Department of Neurosurgery

12800 East 19th Avenue
Room RC1N 7118
Aurora, CO 80045

office: (303) 724-9116

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