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Rapid evaluation of the durability of cortical neural implants using accelerated aging with reactive oxygen species.

Pavel Takmakov, Kiersten Ruda, K Scott Phillips, Irada S Isayeva, Victor Krauthamer, Cristin G Welle


A challenge for implementing high bandwidth cortical brain–machine interface devices in patients is the limited functional lifespan of implanted recording electrodes. Development of implant technology currently requires extensive non-clinical testing to demonstrate device performance. However, testing the durability of the implants in vivo is time-consuming and expensive. Validated in vitro methodologies may reduce the need for extensive testing in animal models.


Here we describe an in vitro platform for rapid evaluation of implant stability. We designed a reactive accelerated aging (RAA) protocol that employs elevated temperature and reactive oxygen species (ROS) to create a harsh aging environment. Commercially available microelectrode arrays (MEAs) were placed in a solution of hydrogen peroxide at 87 C for a period of 7 days. We monitored changes to the implants with scanning …

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Journal of neural engineering





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