Rapid evaluation of the durability of cortical neural implants using accelerated aging with reactive oxygen species.

Pavel Takmakov, Kiersten Ruda, K Scott Phillips, Irada S Isayeva, Victor Krauthamer, Cristin G Welle

Objective:

A challenge for implementing high bandwidth cortical brain–machine interface devices in patients is the limited functional lifespan of implanted recording electrodes. Development of implant technology currently requires extensive non-clinical testing to demonstrate device performance. However, testing the durability of the implants in vivo is time-consuming and expensive. Validated in vitro methodologies may reduce the need for extensive testing in animal models.


Approach:

Here we describe an in vitro platform for rapid evaluation of implant stability. We designed a reactive accelerated aging (RAA) protocol that employs elevated temperature and reactive oxygen species (ROS) to create a harsh aging environment. Commercially available microelectrode arrays (MEAs) were placed in a solution of hydrogen peroxide at 87 C for a period of 7 days. We monitored changes to the implants with scanning …

Publication Date:

2015/1/28

Journal:

Journal of neural engineering

Volume:

12

Issue:

2